# List of abbreviations

ADAM Advanced Dissolution, Absorption and Metabolism

ADME absorption, distribution, metabolism, and excretion

ANDA abbreviated new drug applications

ANN artificial neural networks

API active pharmaceutical ingredient

BCS Biopharmaceutics Classification System

BDCCS Biopharmaceutics Drug Disposition Classification System

CART Classification and Regression Trees

CAT Compartmental Absorption and Transit

CCCD circumscribed central composite design

CCN Cascade Correlation Networks

CCP critical controlled parameters

CFD computational fluid dynamics

CHAID Chi-squared Automatic Interaction Detector

CPP critical process parameters

CPPNN Compositional Pattern-producing Neural Networks

CQA critical quality attributes

DRV dried reconstituted vesicles

DSC differential scanning calorimetry

DSPC 1,2-distearoyl-*sn*-glycero-3-phosphocholine

EA [2-(diethylamino)ethyl] dextran

EDNN Elman Dynamic Neural Network

FaSSIF fasted state simulated intestinal fluid

FCCD face-centered central composite design

GMDNN Gamma Memory Dynamic Neural Network

GRNN generalized regression neural network

HLB hydrophilic lipophilic balance

HN Hetero-associative networks

HNN Hierarchical Neural Network

HPMC hydroxypropyl methylcellulose

ICH International Conference on Harmonization

IPA l-menthol as a penetration enhancer and isopropanol

IVIVC *in vitro-in vivo* correlation

LDA linear discriminant analysis

LVQ Learning Vector Quantization Networks

MAA marketing authorization applications

MLR multiple linear regression

MRT microwave resonance technology

MSC multiplicative scatter correction

MSI multivariate spline interpolation

NIPALS Non-linear iterative PALS

NIRS Near infrared spectroscopy

OLDNN One Layer Dynamic Neural Network

OSC orthogonal signal correction

O/SCoS oil-to-surfactant/cosurfactant

PAT process analytical technology

PCA principal component analysis

PCR principle component regression

PLS-DA PLS discriminant analysis

PNN Probabilistic Neural Networks

PSA Parameter Sensitivity Analysis

Q-IWG quality implementation working group

QSAR quantitative structure–activity relationships

QTPP quality target product profile

RBFNN radial basis function neural network

RMSEC root-mean-square error of calibration

RMSECV root-mean-square error of cross-validation

SECV standard error of cross-validation

SEP standard error of prediction

SIF simulated intestinal fluid

SIMCA soft independent modeling of class analogy

SMEDDS self-microemulsifying drug delivery vehicles

USP United States Pharmacopoeia