List of tables – Computer-Aided Applications in Pharmaceutical Technology

List of tables

1.1. Comparison between the traditional and QbD approaches (ICH Q8 guideline) 6

1.2. Classification of models' contribution in assuring product quality (according to ICH Q-IWG document)  9

1.3. QbD for industry and regulatory bodies  10

3.1. 23 full factorial design  34

3.2. Determination of factor interactions  35

3.3. 24-1 fractional factorial design  35

3.4. Plackett-Burman design for seven factors  36

3.5. CCD for three factors  38

3.6. BBD for three factors (center point is replicated three times)  39

3.7. BBD for three factors (simplified)  39

3.8. Doehlert matrix for two variables  40

3.9. Doehlert matrix for three variables  41

3.10. Factor levels in mixture designs  43

5.1. Equivalent terms in statistics and neural networks  100

5.2. Review of various applications of the ANN methodology  112

6.1. Summary of nimesulide input parameters employed for GI simulation  185

6.2. ASF values employed  187

6.3. Comparison of PK parameters between Model 1 and Model 2 predicted and in vivo observed data  188

6.4. Summary of the GLK input parameters employed for GI simulation  190

6.5. Default and adjusted ASF values  191

6.6. Summary of the CBZ input parameters employed for ACAT model simulation  193

6.7. Summary of the CBZ input parameters employed for GI simulation  197

6.8. Comparison of PK parameters between simulated and in vivo observed data for CBZ following oral administration of a single 400 mg dose from IR tablet in fasted state  197

6.9. GastroPlus™ (version 8.0) interpretation of changes in human physiology between fasted and fed states  207

6.10. IVIVC statistical parameters for GLK IR tablets  211

6.11. The PK parameters predicted based on CBZ IR tablets dissolution in various media  214

6.12. The PK parameters predicted based on CBZ CR tablets dissolution in various media  214

6.13. Etoricoxib: regression analysis output, and percent prediction error statistics  220