Table of Contents – Computer-Aided Applications in Pharmaceutical Technology

Table of Contents

Cover image

Title page


List of figures

List of tables

List of abbreviations

About the editor

About the contributing authors


Chapter 1: Quality-by-design in pharmaceutical development


1.1 Introduction

1.2 ICH Q8 guideline

1.3 Regulatory and industry views on QbD

1.4 Scientifically based QbD - examples of application

1.5 Conclusion

Chapter 2: Computer-aided formulation development


2.1 Introduction

2.2 Application of computer-aided techniques in development of pharmaceutical emulsions

2.3 Application of computer-aided techniques in development of microemulsion drug carriers

2.4 Conclusion

Chapter 3: Experimental design application and interpretation in pharmaceutical technology


3.1 Introduction

3.2 Theory

3.3 Examples

Chapter 4: Chemometric methods application in pharmaceutical products and processes analysis and control


4.1 Introduction

4.2 Theory

4.3 Examples

Chapter 5: Neural computing in pharmaceutical products and process development


5.1 Artificial neural networks

Static neural networks

Construction and testing of the ANN

Unsupervised learning

Limitations of the ANN

5.2 Fuzzy logic

5.3 Decision trees

5.4 Evolutionary computing and genetic algorithms

5.4.1 Theory

5.5 Self-organizing maps

5.6 Conclusion

Chapter 6: Computer-aided biopharmaceutical characterization: gastrointestinal absorption simulation


6.1 Introduction

6.2 Theoretical background

6.3 Model construction

6.4 Parameter sensitivity analysis

6.5 Virtual trial

6.6 Fed vs. fasted state

6.7 In vitro dissolution and in vitro-in vivo correlation

6.8 Biowaiver considerations

6.9 Conclusions

Chapter 7: Computational fluid dynamics: applications in pharmaceutical technology


7.1 Introduction

7.2 Theoretical background

7.3 Application of CFD in pharmaceutical technology

7.4 Conclusion